Table 1 List of the 60 selected genes
From: NF-kappa B genes have a major role in Inflammatory Breast Cancer
Gene symbols | Alternate symbols | Gene name | Chromosome location | Genbank accession number |
|---|---|---|---|---|
NFKB genes (n = 11) | ||||
NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 4q24 | NM_003998 | |
NFKB2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 10q24 | NM_002502 | |
REL | v-rel reticuloendotheliosis viral oncogene homolog | 2p13-p12 | NM_002908 | |
RELA | NFKB3 | v-rel reticuloendotheliosis viral oncogene homolog A (p65) | 11q13 | NM_021975 |
RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 19q13.32 | NM_006509 | |
CHUK | IKBKA | Conserved helix-loop-helix ubiquitous kinase | 10q24-q25 | NM_001278 |
IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 8p11.2 | NM_001556 | |
IKBKG | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Xq28 | NM_003639 | |
NLK | Nemo like kinase | 17q11.2 | NM_016231 | |
NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 14q13 | NM_020529 | |
NFKBIB | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 19q13.1 | NM_1001716 | |
Apoptosis (n = 12) | ||||
BCL2A1 | BFL1/A1 | Baculoviral IAP repeat-containing 2 | 15q24.3 | NM_004049 |
GADD45B | Growth arrest and DNA-damage-inducible, beta | 19p13.3 | NM_015675 | |
TNFRSF10B | TRAILR2, DR5 | Tumor necrosis factor receptor superfamily, member 10b | 8p22-p21 | NM_003842 |
FASLG | FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) | 1q23 | NM_000639 |
BIRC4 | XIAP | Baculoviral IAP repeat-containing 4 | Xq25 | NM_001167 |
TNFAIP3 | A20 | Tumor necrosis factor, alpha-induced protein 3 | 6q23 | NM_006290 |
TRAF2 | TNF receptor-associated factor 2 | 9q34 | NM_021138 | |
IER3S | Immediate early response 3, large transcript | 6p21.3 | NM_003897 | |
IER3L | Immediate early response 3, short transcript | 6p21.3 | NM_052815 | |
BIRC2 | c-IAP1 | Baculoviral IAP repeat-containing 2 | 11q22 | NM_001166 |
MCL1S | Myeloid cell leukemia sequence 1 (BCL2-related), short transcript | 1q21 | NM_182763 | |
MCL1L | Myeloid cell leukemia sequence 1 (BCL2-related), large transcript | 1q21 | NM_021960 | |
Immune response (n = 15) | ||||
IL1A | Interleukin 1, alpha | 2q14 | NM_000575 | |
IL1B | Interleukin 1, beta | 2q14 | NM_000576 | |
IL6 | Interleukin 6 (interferon, beta 2) | 7p21 | NM_000600 | |
IL12B | Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q31.1-q33.1 | NM_002187 | |
IL15 | Interleukin 15 | 4q31 | NM_000585 | |
CCL2 | MCP-1 | Chemokine (C-C motif) ligand 2 | 17q11.2-q21.1 | NM_002982 |
CCR5 | Chemokine (C-C motif) receptor 5 | 3p21 | NM_000579 | |
TNFRSF11A | RANK | Tumor necrosis factor receptor superfamily, member 11a, activator of NFKB | 18q22.1 | NM_003839 |
TNFSF11 | RANKL | Tumor necrosis factor (ligand) superfamily, member 11 | 13q14 | NM_003701 |
TNF | Tumor necrosis factor (TNF superfamily, member 2) | 6p21.3 | NM_000594 | |
IRF7 | Interferon regulatory factor 7 | 11p15.5 | NM_001572 | |
GBP1 | Guanylate binding protein 1, interferon-inducible, 67kDa | 1p22.2 | NM_002053 | |
CD40 | CD40 antigen (TNF receptor superfamily member 5) | 20q12-q13.1 | NM_001250 | |
CD40LG | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | Xq26 | NM_000074 | |
CD48 | CD48 molecule | 1q21.3-q22 | NM_001778 | |
Cell Proliferation (n = 8) | ||||
CSF1 | Colony stimulating factor 1 (macrophage) | 1p21-p13 | NM_000757 | |
CSF1R | Colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 5q33-q35 | NM_005211 | |
CSF2 | Colony stimulating factor 2 (granulocyte-macrophage) | 5q31.1 | NM_000758 | |
CCND1 | Cyclin D1 (PRAD1: parathyroid adenomatosis 1) | 11q13 | NM_053056 | |
CCND2 | Cyclin D2 | 12p13 | NM_001759 | |
CCND3 | Cyclin D3 | 6p21.3 | NM_001760 | |
CCNG1 | Cyclin G1 | 5q32-q34 | NM_004060 | |
SOD2 | Mn-SOD | Superoxide dismutase 2, mitochondrial | 6q25.3 | NM_000636 |
Tumor progression (n = 10) | ||||
MMP9 | Matrix metalloproteinase 9 (gelatinase B, 92 kDa type IV collagenase) | 20q11.2-q13.1 | NM_004994 | |
MMP11 | Matrix metalloproteinase 11 (stromelysin 3) | 22q11.23 | NM_005931 | |
PLAU | UPA | Plasminogen activator, urokinase | 10q24 | NM_002658 |
CTSB | Cathepsin B | 8p22 | NM_001908 | |
CXCR4 | Chemokine (C-X-C motif) receptor 4 | 2q21 | NM_003467 | |
CXCL12 | SDF1 | Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 10q11.1 | NM_000609 |
ICAM1 | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 19p13.3-p13.2 | NM_000201 | |
VCAM1 | Vascular cell adhesion molecule 1 | 1p32-p31 | NM_001078 | |
SELE | ELAM1 | Selectin E (endothelial adhesion molecule 1) | 1q22-q25 | NM_000450 |
TNC | HXB | Tenascin C (hexabrachion) | 9q33 | NM_002160 |
Angiogenesis (n = 4) | ||||
IL8 | Interleukin 8 | 4q13-q21 | NM_000584 | |
CXCL1 | GRO1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 4q21 | NM_001511 |
VEGF | VEGFA | Vascular endothelial growth factor | 6p12 | NM_003376 |
PTGS2 | COX2 | Prostaglandin-endoperoxide synthetase 2 | 1q25.2-q25.3 | NM_000963 |