Marker | High IHC score | PDAC (%) | Duct (%) | p-value |
---|---|---|---|---|
Cytoplasm | ||||
p-JNK | ≥ 2 | 77 | 4 | <0.0001 |
p-ERK | ≥ 2 | 62 | 8 | <0.0001 |
p-SRC | ≥ 2 | 73 | 40 | 0.0005 |
S727 p-STAT3 | ≥ 3 | 38 | 4 | 0.005 |
T308 p-PKB | ≥ 2 | 69 | 12 | <0.0001 |
p-S6K | ≥2 | 27 | 16 | 0.5 |
S473p-PKB | ≥2 | 15 | 0 | 0.1 |
p-NFκB | ≥2 | 19 | 4 | 0.2 |
p-S6 | ≥2 | 54 | 40 | 0.4 |
p-p38 | ≥ 2 | 65 | 20 | 0.002 |
Y705 p-STAT3 | ≥ 2 | 85 | 26 | 0.0005 |
p-GSK3β | ≥ 3 | 50 | 12 | 0.006 |
p-mTOR | ≥ 3 | 19 | 0 | 0.05 |
p-RAF | ≥ 3 | 62 | 24 | 0.01 |
p-βCAT | ≥ 2 | 42 | 96 | <0.0001 |
Nucleus | ||||
p-NFκB | ≥3 | 50 | 56 | 1 |
p-ERK | ≥ 3 | 62 | 16 | 0.001 |
p-p38 | ≥ 3 | 62 | 20 | 0.004 |
p-JNK | ≥ 3 | 26 | 0 | 0.01 |
T308p-PKB | ≥3 | 27 | 8 | 0.1 |
S727p-STAT3 | ≥2 | 77 | 80 | 1 |
S473 p-PKB | ≥ 2 | 62 | 16 | 0.001 |
Y705p-STAT3 | ≥2 | 69 | 56 | 0.4 |
p-βCAT | ≥2 | 35 | 32 | 1 |
p-GSK3β | ≥1 | 23 | 20 | 1 |