Figure 1From: Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma Expression of miR-21 in 5 patients presenting simultaneously with normal breast epithelium, FEA, DCIS by RNA ISH. The expression of miR-21 was detected predominantly in the cytoplasm in luminal cells. An increase in staining intensity for miR-21 was observed from normal, to FEA and DCIS in these 5 patients. Staining intensity in FEA and DCIS was similar in 4 out of 5 cases (200×).Back to article page