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Table 2 The cytotoxic effect of LfcinB against lymphoma cell lines expressing different levels of HS.

From: The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells

Cell line

aCell surface HS

bIC50(μM)

KMS-5

+

38

U-266

+

55

KMM-1

+

57

Sudhl-4

-

16

Raji

-

13

Ramos

-

10

  1. aCell surface HS was measured using an anti-HS antibody and flow cytometry. Cell lines marked with + express HS, while cell lines marked with -lack HS.
  2. bIC50 is the inhibitory concentration of the LfcinB peptide in (μM) where 50% of the cells are killed.
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BMC Cancer

ISSN: 1471-2407

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