Table 4 FH of malignant tumor in first degree relatives and survival from UGI cancer *
From: Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China
| Â | Â | ESCC | GCA | GNCA | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | FH | Case | Death | HR (95% CI) | Case | Death | HR (95% CI) | Case | Death | HR (95% CI) |
Any malignant tumor | - | 379 | 232 | 1 | 384 | 278 | 1 | 210 | 134 | 1 |
|  | + | 190 | 113 | 1.09(0.86–1.36) | 146 | 96 | 0.80(0.63–1.01) | 85 | 60 | 1.22(0.88–1.68) |
Any UGI cancer | - | 443 | 268 | 1 | 434 | 309 | 1 | 245 | 164 | 1 |
|  | + | 126 | 77 | 1.06(0.82–1.38) | 96 | 65 | 0.82(0.62–1.08) | 50 | 30 | 0.85(0.56–1.28) |
0 affected | - | 443 | 268 | 1 | 434 | 309 | 1 | 245 | 164 | 1 |
1 affected | + | 109 | 69 | 1.15(0.88–1.50) | 82 | 55 | 0.80(0.60–1.07) | 43 | 23 | 0.73(0.46–1.15) |
≥2 affected | + | 17 | 8 | 0.64(0.32–1.30) | 14 | 10 | 0.94(0.48–1.84) | 7 | 7 | 1.82(0.84–3.97) |
<50 | + | 23 | 19 | 1.82(1.01–3.29) | 8 | 7 | 2.30(0.85–6.20) | 16 | 8 | 0.96(0.38–2.38) |
>=50 | + | 103 | 58 | 0.92(0.68–1.22) | 88 | 58 | 0.76(0.57–1.02) | 34 | 22 | 0.78(0.49–1.26) |
Esophageal cancer | - | 479 | 291 | 1 | 481 | 342 | 1 | 268 | 174 | 1 |
|  | + | 90 | 54 | 0.97(0.72–1.31) | 49 | 32 | 0.81(0.56–1.18) | 27 | 20 | 1.03(0.63–1.68) |
Gastric cardia cancer | - | 546 | 327 | 1 | 504 | 356 | 1 | 284 | 189 | 1 |
|  | + | 23 | 18 | 1.61(0.99–2.61) | 26 | 18 | 0.88(0.54–1.42) | 11 | 5 | 0.66(0.26–1.64) |
Gastric noncardia cancer | - | 550 | 336 | 1 | 503 | 356 | 1 | 279 | 185 | 1 |
|  | + | 19 | 9 | 0.80(0.41–1.56) | 27 | 18 | 0.76(0.47–1.22) | 16 | 9 | 0.96(0.48–1.91) |
Non-UGI cancer | - | 505 | 309 | 1 | 480 | 343 | 1 | 260 | 164 | 1 |
|  | + | 64 | 36 | 1.10(0.77–1.56) | 50 | 31 | 0.82(0.56–1.20) | 35 | 30 | 1.73(1.16–2.60) |