Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment

Table 4 Univariate and multivariate analysis of prognostic indicators on overall survival for colorectal cancer patients

Parameters	Number	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI) P value		Hazard ratio (95% CI) P value
Age (≥65/<65) years	743/624	1.30(1.09–1.56)	0.004	1.85(1.41–2.43)	<0.001
Sex (Male/Female)	757/610	1.22(1.03–1.46)	0.026	-	0.186
Site (Colon/Rectum)	920/447	1.20(0.99–1.45)	0.066	-	-
Tumor size (≥5/<5) cm	593//774	1.24(1.03–1.50)	0.026	-	0.256
BMI^a (≥24/<18.5–24/<18.5)	434/516/417	0.84(0.66–1.09)	0.186	-	-
Albumin (<3.5/≥3.5) gm/dl	392/975	1.70(1.38–2.10)	<0.001	-	0.072
Histology (PD/MD/WD^b)	118/1066/183	2.92(1.91–4.49)	<0.001	-	0.245
UICC^c stage (III&IV/I&II)	630/737	3.45(2.84–4.18)	<0.001	3.09(2.34–4.07)	<0.001
CEA^d(≥5/<5) ng/ml	643/724	2.74(2.23–3.37)	<0.001	2.28(1.73–3.01)	<0.001

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