Figure 3

Side effects associated with the adoptive transfers. A) Incidental rates as a result of the leukocyte transfer. "W" (61%) refers to successful transfer of anticancer activity and protection of the recipient mice from subsequent challenges with S180. "X" (31%) refers to the animals that developed S180-induced ascites presumably due to the rejection of donor leukocytes by the recipients. "Y" (5.5%) refers to the deaths of recipient mice after the transfer of donor leukocytes due to unknown reasons, but not due to development of ascites. "Z" (2.5%) refers to an incident of fur discoloration post-adoptive transfer potentially representing graft-versus-host disease. B) An image of fur discoloration as a result of donor leukocyte transfers. C) Skin histology under discolored fur indicates post inflammatory pigment incontinence. The black arrows point to areas with normal appearing pigmentation while the green arrows point to the areas of pigment incontinence in which the pigment localized in macrophages at the periphery of the follicles.