| HIF-1α mRNA | HIF-1α protein | ||||
---|---|---|---|---|---|---|
 | low | high | P | low | high | P |
Patients | 68 | 42 | Â | 71 | 39 | Â |
Age(years) | Â | Â | Â | Â | Â | Â |
   ≤52 | 28 | 26 | 0.049 | 32 | 22 | 0.320 |
   >52 | 40 | 16 |  | 39 | 17 |  |
Sex | Â | Â | Â | Â | Â | Â |
   Male | 57 | 38 | 0.40 | 57 | 38 | 0.017 |
   Female | 11 | 4 |  | 14 | 1 |  |
Hepatitis history | Â | Â | Â | Â | Â | Â |
   Yes | 61 | 39 | 0.739 | 62 | 38 | 0.094 |
   No | 7 | 3 |  | 9 | 1 |  |
Preoperative AFP(ng/ml) | Â | Â | Â | Â | Â | Â |
   ≤20 | 29 | 16 | 0.693 | 33 | 12 | 0.156 |
   >20 | 39 | 26 |  | 38 | 27 |  |
Liver cirrhosis | Â | Â | Â | Â | Â | Â |
   Yes | 59 | 34 | 0.428 | 56 | 37 | 0.029 |
   No | 9 | 8 |  | 15 | 2 |  |
ALT(U/L) | Â | Â | Â | Â | Â | Â |
   ≤40 | 36 | 22 | 1.000 | 38 | 20 | 0.844 |
   >40 | 32 | 20 |  | 33 | 19 |  |
Γ-GT(U/L) |  |  |  |  |  |  |
   ≤54 | 30 | 14 | 0.318 | 31 | 13 | 0.316 |
   >54 | 38 | 28 |  | 40 | 26 |  |
Tumor size (cm) | Â | Â | Â | Â | Â | Â |
   ≤5 | 35 | 21 | 1.000 | 33 | 23 | 0.236 |
   >5 | 33 | 21 |  | 38 | 16 |  |
Tumor encapsulation | Â | Â | Â | Â | Â | Â |
   Yes | 31 | 18 | 0.845 | 32 | 17 | 1.000 |
   No | 37 | 24 |  | 39 | 22 |  |
Tumor number | Â | Â | Â | Â | Â | Â |
   Single | 53 | 32 | 0.820 | 56 | 29 | 0.638 |
   Multiple | 15 | 10 |  | 15 | 10 |  |
Vascular invasion | Â | Â | Â | Â | Â | Â |
   Yes | 26 | 25 | 0.033 | 27 | 24 | 0.027 |
   No | 42 | 17 |  | 44 | 15 |  |
BCLC stage | Â | Â | Â | Â | Â | Â |
   A | 30 | 10 | 0.041 | 31 | 9 | 0.039 |
   B + C | 38 | 32 |  | 40 | 30 |  |
Tumor differentiation | Â | Â | Â | Â | Â | Â |
   I+II | 40 | 18 | 0.119 | 36 | 22 | 0.690 |
   III+IV | 28 | 24 |  | 35 | 17 |  |
Prophylactic treatment | Â | Â | Â | Â | Â | Â |
   Yes | 33 | 22 | 0.845 | 31 | 24 | 0.110 |
   No | 35 | 20 |  | 39 | 16 |  |