Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

Table 3 Correlations between HIF-1α mRNA and other molecular markers as well as prognostic significance.

	HIF-1α	COX-2	MMP7	PDGFRA	MMP9	MYC	VEGF
Correlation (P)	0.000	< 0.001	< 0.001	< 0.001	< 0.001	0.016	0.183
Coefficient (r)	1.000	0.708	0.593	0.493	0.384	0.230	0.128
OS (P)	0.012	0.004	0.010	0.010	NS	NS	NS
DFS (P)	0.004	0.010	NS	0.038	NS	NS	NS

Detailed legends: The P values for correlation were determined by spearman's coefficience. The P values for OS and DFS were calculated using multivariate Cox proportional hazards analysis. All factors were presented in different multivariable analysis respectively and variables were adopted for their prognostic significance by univariate analysis. NS means not significant (P > 0.05).

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