Figure 1
From: c.1810C>T Polymorphism of NTRK1Gene is associated with reduced Survival in Neuroblastoma Patients
Sequence variants of the NTRK1 gene identified in the present study. The structure of TrkA receptor. Extracellular part of the protein consists of: two cysteine clusters (Cys); three leucine-rich motifs (LRM) and two immunoglobulin-like C2 domains (Ig-C2). It is followed by a short transmembrane portion (TM), and intracellular juxtamembrane domain (JM) and tyrosine kinase domain (TK). * - newly identified sequence variants, circled - the SNPs having MAF (minor allele frequency) value >5%, arrows - exonic localization of the variants, dishes - intronic localization of the variants.