Figure 1
From: Mutation analysis of the AATF gene in breast cancer families
Schematic diagram of AATF protein structure and location of observed missense variant. Structure and main functional domains of AATF are shown. Leucine zipper motif location (aa 275-296) is marked in dark grey, with the basic domain in horizontal stripes (aa 133-145). Nuclear translocation signal is shown in diagonal stripes (aa 338-344). Three nuclear receptor binding motifs are marked in light grey (aa 11-15, 281-285, 520-524). The location of the observed amino acid alteration is shown by an arrow (functional domain structure modified mainly from reference [9]).