Figure 4
Efficacy of antihormonal agents on HeLa cell tumors treated with cisplatin or radiotherapy. HeLa cells were implanted s.c. in both hind limbs of nude mice. Treatment was initiated when the tumors reached 150 mm3. Mifepristone (A) or ICI (B) were administered in combination with radiation, cisplatin, and radiation/cisplatin. B) ICI was also administered in combination with radiation, cisplatin, and radiation/cisplatin. As controls, tumor growth was determined for mice treated only with the vehicle. Data are presented as the mean ± SEM of five to six animals. (*) indicates a significant difference (p < 0.01) between the triple combination groups vs control group; (#) and (†) represent a significant difference vs the dual treatments (p < 0.05) and individual treatments (p < 0.01) respectively.