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Table 3 Cox regression analysis for overall survival in TNBC

From: Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients

Parameters

Univariate

Multivariate

p-value

HR, 95% CI

p-value

Age (≤50 years vs >50 years)

0.06

1.79 (0.04-136.2)

0.68

Menopausal Status (Pre- vs Post-)

0.08

1.18 (0.08-127.6)

0.93

Tumour size (pT1 vs pT2-T3)

0.06

2.10 (0.30-14.4)

0.44

Lymph node status (pN0 vs pN+)

0.05

4.29 (0.65-28.13)

0.13

Nuclear Grade (G1-G2 vs G3)

0.28

0.64 (0.10-3.84)

0.62

Ki-67 (≤20% vs >20%)

0.75

1.49 (0.21-10.30)

0.68

Lympho-vascular invasion (absence vs presence)

0.16

4.95 (0.60-40.30)

0.13

Necrosis (absence vs presence)

0.009

6.92 (1.48-32.35)

0.01

Intraductal carcinoma (absence vs presence)

0.94

1.36 (0.22-8.17)

0.73

NLR (≤3 vs >3)

0.003

6.16 (1.54 – 24.66)

0.01

  1. Table 3 shows a significant correlation between OS and either higher pre-treatment NLR and necrosis.
  2. Legend: NLR = Neutrophil to Lymphocyte Ratio; HR = hazard ratio; CI = confidence interval.