Figure 2From: A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancerKaplan–Meier plots of PFS and OS according to KRAS, NRAS, BRAF and PIK3CA gene status. A) The median PFS was 5.8 months (95% CI, 4.8–6.7) among patients with all wild-type tumors (n = 56) and was 2.2 months (1.9–2.5) among those with mutations in KRAS codons 61 or 146, BRAF, NRAS or PIK3CA (n = 10). Differences in PFS between patients with all wild-type tumors and those with mutations in KRAS codons 61 or 146, BRAF, NRAS, or PIK3CA were statistically significant (HR, 3.38; 95% CI, 1.65–6.93; P = 0.001). B) The median OS was 17.7 months (95% CI, 1.1–34.3) among patients with all wild-type tumors (n = 56) and was 5.2 months (3.8–6.6) among those with mutations in KRAS codons 61 or 146, BRAF, NRAS or PIK3CA (n = 10). Differences in OS values between patients with all wild-type tumors and those with mutations in KRAS codons 61 or 146, BRAF, NRAS or PIK3CA were statistically significant (HR, 4.94; 95% CI, 2.12–11.5; P < 0.001).Back to article page