Table 2 Univariate and multivariate analyses of different prognostic factors in 1148 patients with gastric carcinoma for disease-specific survival

Sex

0.800

  Female

354

Reference

  Male

794

0.977 (0.817-1.169)

Age at diagnosis (years)

0.046

1.170 (0.960-1.425)

0.120

  ≤59

574

Reference

  >59

574

1.184 (1.003-1.398)

CEA^†

0.082

  Normal

791

Reference

  Elevated

157

1.231 (0.974-1.556)

CA19-9^‡

0.001

1.098 (0.878-1.374)

0.411

  Normal

707

Reference

  Elevated

195

1.438 (1.155-1.791)

Size (diameter), cm

<0.0001

1.311 (1.077-1.595)

0.007

  ≤5

697

Reference

  >5

451

1.695 (1.436-2.000)

Lauren classification

<0.0001

0.836 (0.619-1.129)

0.243

  Diffuse

585

Reference

  Mixed/ Intestinal

563

0.740 (0.627-0.875)

Differentiation

<0.0001

1.126 (0.816-1.554)

0.471

  Well/moderate

435

Reference

  Poor/undifferentiated

713

1.445 (1.211-1.724)

Gastric wall invasion

<0.0001

2.284 (1.413-3.691)

0.001

  T1/T2

150

Reference

  T3/T4

998

4.643 (3.083-6.991)

Nodal metastasis

<0.0001

0.806 (0.573-1.134)

0.216

  N0

377

Reference

  N1-N3

771

2.529 (2.061-3.102)

Distant metastasis

<0.0001

2.365 (1.851-3.022)

<0.0001

  M0

1003

Reference

  M1

145

3.479 (2.832-4.272)

TNM stage

<0.0001

2.090 (1.462-2.988)

<0.0001

  I/II

486

Reference

  III/ IV

662

3.039 (2.516-3.670)

Vascular invasion

<0.0001

1.438 (1.171-1.766)

0.001

  Absent

744

Reference

  Present

404

2.121 (1.795-2.506)