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Fig. 9 | BMC Cancer

Fig. 9

From: Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer

Fig. 9

Apoptotic mechanisms in MDA-MB-231 and MCF-7 cells following treatment with Apo-bLf and Fe-bLf. BLf is internalized by membrane bound receptors such as Lf receptors via receptor mediated endocytosis. Once internalized, bLf modulates various apoptotic molecules as indicated by the red arrows. This modulation is cell specific as well as bLf form specific as some molecules are only activated or inhibited by one form of bLf

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BMC Cancer

ISSN: 1471-2407

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