Fig. 8From: The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenograftsExposure to the MSM-Tam combination downregulated the STAT5b/IGF-1Rβ signaling pathway. (a) Immunofluorescence analysis of STAT5b and IGF-1Rβ showing the inhibition ability of the drug combination. (b) Western blotting analysis of various tissue protein levels after treatment with the drug combination or the individual agents for 24 h. (c) Relative expression of tissue protein levels following exposure to Tam, MSM, or their combinationBack to article page