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Table 2 18 miRNAs significantly differentially expressed between ER+ and ER− breast tumors in the screening series

From: MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?

Official name

Normal breast tissue (n = 8)

ER+ breast tumors (n = 21)

ER− breast tumors (n = 10)

ER+/ER−

FC

p-value

11 miRNAs up-regulated in ER+ compared to ER− with a FC > 2

miR-190b

1.0 (0.06-3.33)

14.5 (2.41-51.7)

0.46 (0.07-6.33)

31.26

<0.0001

miR-101-1

1.0 (0.00-2.21)

0.40 (0.05-1.23)

0.08 (0.01-0.48)

4.94

0.0033

miR-193b

1.0 (0.12-2.65)

1.87 (0.20-8.68)

0.48 (0.24-2.37)

3.89

0.0106

miR-342-5p

1.0 (0.63-1.74)

2.61 (0.30-7.37)

0.94 (0.32-2.87)

2.77

0.0296

miR-376c

1.0 (0.00-3.40)

0.53 (0.19-1.40)

0.20 (0.01-0.59)

2.60

0.0083

miR-451

1.0 (0.01-3.47)

0.15 (0.04-1.78)

0.06 (0.00-0.19)

2.55

0.0019

miR-143

1.0 (0.01-2.24)

0.26 (0.10-1.11)

0.10 (0.01-0.35)

2.52

0.0094

miR-30c2

1.0 (0.04-8.70)

1.99 (0.15-11.3)

0.87 (0.07-3.41)

2.29

0.0329

miR-30e

1.0 (0.11-9.13)

3.02 (0.29-13.6)

1.41 (0.08-5.73)

2.15

0.0405

miR-26a1

1.0 (0.09-2.57)

0.59 (0.28-3.86)

0.28 (0.08-0.86)

2.10

0.0014

miR-26b

1.0 (0.08-2.57)

0.52 (0.21-2.79)

0.25 (0.04-0.66)

2.10

0.0050

7 miRNAs down-regulated in ER+ compared to ER− with a FC > 4

miR-654-3p

1.0 (0.15-4.36)

0.58 (0.10-4.89)

4.25 (0.68-41.6)

−7.29

0.0008

miR-203

1.0 (0.16-3.97)

1.54 (0.12-48.9)

8.86 (1.30-36.4)

−5.76

0.0073

miR-146a

1.0 (0.07-2.95)

0.70 (0.07-4.48)

3.71 (0.27-15.3)

−5.30

0.0106

miR-494

1.0 (0.24-3.18)

0.20 (0.03-1.68)

0.99 (0.11-1.86)

−4.97

0.0191

miR-338-5p

1.0 (0.51-5.60)

0.40 (0.19-1.07)

1.92 (0.67-3.41)

−4.82

<0.0001

miR-891a

1.0 (0.24-2.43)

0.34 (0.17-1.28)

1.63 (0.28-2.81)

−4.77

0.0025

miR-1244

1.0 (0.22-3.30)

1.12 (0.09-2.79)

4.86 (0.76-17.5)

−4.33

0.0050

  1. Results in ER+ and ER− tumors are expressed as the median (range) of miRNA level relative to normal breast tissues and the difference in miRNA expression between ER+ and ER− were analysed for significance with the Mann–Whitney test. The miRNAs are ranked according to the fold change (FC) calculated between ER+ and ER−
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BMC Cancer

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