Skip to main content

Table 4 Relative miRNA expression levels of the 30 selected miRNAs between ER+ or ER− breast tumors and normal breast tissues

From: MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?

Official Name

Normal breast tissue (n = 8)

ER+ breast tumors  (n= 85)

ER+/Normal

ER− breast tumors  (n= 68)

ER−/Normal

FC

p-value

FC

p-value

12 miRNAs up-regulated in ER+ compared to ER−

miR-190b

1.0 (0.32-1.57)

6.34 (0.71-32.3)

6.34

<0.0001

0.27 (0.02-6.23)

−3.70

0.0284

miR-26a1

1.0 (0.77-4.06)

0.34 (0.11-1.78)

−2.94

<0.0001

0.09 (0.02-0.47)

−11.11

<0.0001

miR-342-5p

1.0 (0.78-2.16)

2.03 (0.29-19.4)

2.03

0.0026

0.93 (0.10-3.65)

−1.07

ns

miR-101-1

1.0 (0.69-8.05)

0.30 (0.05-2.10)

−3.33

<0.0001

0.15 (0.01-0.92)

−6.67

<0.0001

let-7b

1.0 (0.71-1.69)

0.53 (0.08-2.04)

−1.89

0.0007

0.31 (0.04-0.82)

−3.23

<0.0001

miR-30e

1.0 (0.70-2.98)

0.79 (0.12-4.57)

−1.27

ns

0.47 (0.10-2.28)

−2.13

0.0005

miR-30c2

1.0 (0.69-1.72)

0.54 (0.12-3.06)

−1.85

0.0032

0.34 (0.09-1.17)

−2.94

<0.0001

miR-143

1.0 (0.45-2.72)

0.21 (0.03-1.40)

−4.76

<0.0001

0.14 (0.02-0.74)

−7.14

<0.0001

miR-26b

1.0 (0.68-4.38)

0.49 (0.15-2.93)

−2.04

0.0034

0.34 (0.06-1.64)

−2.94

0.0001

miR-376c

1.0 (0.52-3.04)

0.14 (0.02-1.55)

−7.14

<0.0001

0.10 (0.02-0.83)

−10.00

<0.0001

miR-193b

1.0 (0.43-1.79)

1.44 (0.10-9,17)

1.44

ns

1.00 (0.11-4.45)

1.00

ns

let-7a

1.0 (0.73-1.79)

0.58 (0.15-2.00)

−1.72

0.0017

0.47 (0.11-2.99)

−2.13

0.0002

8 miRNAs down-regulated in ER+ compared to ER−

miR-18a

1.0 (0.49-3.33)

0.50 (0.06-2.53)

−2.00

0.0074

1.12 (0.12-23.9)

1.12

ns

miR-654-3p

1.0 (0.72-1.34)

0.30 (0.05-2.68)

−3.33

0.0001

0.66 (0.04-17.8)

−1.51

ns

miR-18b

1.0 (0.47-4.45)

0.50 (0.07-3.52)

−2.00

0.0063

1.04 (0.13-25.3)

1.04

ns

miR-155

1.0 (0.55-4.24)

2.06 (0.52-10.9)

2.06

0.0181

3.97 (0.35-32.0)

3.97

0.0019

miR-1244

1.0 (0.73-1.69)

1.23 (0.16-5.11)

1.23

ns

2.34 (0.35-25.3)

2.34

0.0073

miR-203

1.0 (0.51-2.43)

0.88 (0.02-5.78)

−1.14

ns

1.51 (0.05-19.6)

1.51

ns

miR-92a1

1.0 (0.68-1.40)

0.32 (0.10-1.17)

−3.12

<0.0001

0.49 (0.09-8.95)

−2.04

0.0007

miR-146a

1.0 (0.54-3.71)

0.70 (0.07-3.63)

−1.43

ns

0.95 (0.10-4.25)

−1.05

ns

10 miRNAs not differentially expressed in ER+ compared to ER−

miR-451

1.0 (0.32-11.1)

0.17 (0.02-14.0)

−5.88

0.0009

0.14 (0.01-9.77)

−7.14

0.0003

miR-21

1.0 (0.49-5.26)

2.05 (0.41-16.6)

2.05

0.0269

1.84 (0.21-9.53)

1.84

ns

miR-22

1.0 (0.38-4.51)

0.71 (0.12-12.9)

−1.41

ns

0.66 (0.09-3.36)

−1.51

ns

miR-494

1.0 (0.85-2.17)

0.65 (0.02-6.96)

−1.54

0.0462

0.69 (0.02-9.03)

−1.45

0.0449

miR-338-5p

1.0 (0.79-1.78)

0.84 (0.19-4.66)

−1.19

ns

0.96 (0.12-5.08)

−1.04

ns

miR-19a

1.0 (0.70-2.13)

0.34 (0.03-2.61)

−2.94

0.0003

0.42 (0.02-14.4)

−2.38

0.0037

miR-222

1.0 (0.63-2.30)

0.39 (0.06-2.68)

−2.56

0.0001

0.50 (0.04-3.88)

−2.00

0.0015

miR-206

1.0 (0.01-2.28)

0.25 (0.02-7.71)

−4.00

0.0156

0.32 (0.01-2.74)

−3.12

0.0114

miR-221

1.0 (0.65-1.92)

0.40 (0.07-4.24)

−2.50

0.0004

0.53 (0.05-5.55)

−1.89

0.0098

miR-891a

1.0 (0.77-1.64)

1.37 (0.14-8.43)

1.37

ns

2.07 (0.37-15.5)

2.07

0.0381

  1. Results in ER+ and ER− breast tumors are expressed as the median (range) of miRNA level relative to normal breast tissues. For each miRNA, we report the fold-change (FC) between ER+ or ER− breast tumors and normal breast tissue and the p-value associated to Mann-Whitney’s test (ns for not significant)
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us