Genotypes | Controls, n (%) | Cases, n (%) | OR (95 % CI) | P value |
---|---|---|---|---|
IL-10 -3575 | ||||
TT | 278(93) | 117(94) | 1 | |
TA | 22(7) | 8(6) | 0.86(0.37-1.99) | 0.73 |
AA | 0 | 0 | ||
T | 578(96) | 242(97) | 1 | |
A | 22(4) | 8(3) | 0.87(0.38-1.98) | 0.73 |
IL-10 -1082 | ||||
AA | 237(79) | 101(81) | 1 | |
AG | 60(20) | 24(19) | 0.94(0.55-1.59) | 0.81 |
GG | 3(1) | 0(0) | ||
A | 534(89) | 226(90) | 1 | |
G | 66(11) | 24(10) | 0.86(0.52-1.41) | 0.55 |
IL-10 -819 | ||||
CC | 39(13) | 9(7) | 1 | |
CT | 125(42) | 59(47) | 2.00(0.93-4.49) | 0.08 |
TT | 136(45) | 57(46) | 1.81(0.83-3.99) | 0.14 |
C | 203(34) | 76(30) | ||
T | 397(66) | 174(70) | 1.17(0.85-1.61) | 0.33 |
IL-10 -592 | ||||
CC | 38(13) | 9(7) | 1 | |
AC | 124(41) | 59(47) | 2.00(0.91-4.43) | 0.08 |
AA | 138(46) | 57(46) | 1.74 (0.79-3.84) | 0.17 |
C | 200(33) | 77(31) | 1 | |
A | 400(67) | 173(69) | 1.12(0.82-1.54) | 0.47 |
TNF-α -857 | ||||
CC | 239(79) | 96(78) | 1 | |
CT | 56(19) | 28(22) | 1.25(0.75-2.08) | 0.40 |
TT | 5(1) | 1(0) | 0.50(0.06-4.32) | 0.53 |
C | 534(89) | 220(88) | 1 | |
T | 66(11) | 30(12) | 1.10(0.69-1.75) | 0.68 |
TNF-α -308 | ||||
GG | 260(87) | 115(92) | 1 | |
AG | 40(13) | 10(8) | 0.56 (0.27-1.17) | 0.12 |
AA | 0 | 0 | ||
G | 560(93) | 240(96) | 1 | |
A | 40(7) | 10(4) | 0.58 (0.29-1.19) | 0.14 |
TNF-α -238 | ||||
GG | 267(89) | 116(93) | 1 | |
AG | 32(11) | 9(7) | 0.65(0.30-1.40) | 0.27 |
AA | 1(0) | 0(0) | - | |
G | 566(94) | 241(96) | 1 | |
A | 34(6) | 9(4) | 0.62(0.29-1.32) | 0.21 |
LTA +252 | ||||
GG | 56(19) | 9(7) | 1 | |
GA | 149(50) | 71(57) | 2.95(1.34-6.48) | 0.01* |
AA | 95(31) | 45(36) | 2.97(1.39-6.33) | 0.01* |
GA + AA | 244(81) | 116(93) | 2.96(1.42-6.19) | 0.004* |
G | 261(44) | 89(36) | 1 | |
A | 339(56) | 161(64) | 1.39(1.03-1.89) | 0.03* |
CTLA-4 -1661 | ||||
AA | 216(72) | 84(67) | 1 | |
AG | 78(26) | 40(32) | 1.32(0.84-2.08) | 0.24 |
GG | 6(2) | 1(0) | 0.43(0.05-3.61) | 0.44 |
G | 90(15) | 42(17) | 1 | |
A | 510(85) | 208(83) | 0.87(0.59-1.30) | 0.51 |
CTLA-4 -318 | ||||
CC | 222(74) | 88(70) | 1 | |
CT | 73(24) | 36(29) | 1.24(0.78-1.99) | 0.36 |
TT | 5(2) | 1(0) | 0.51(0.05-4.38) | 0.54 |
C | 517(86) | 212(85) | 1 | |
T | 83(14) | 38(15) | 1.11(0.74-1.69) | 0.60 |
CTLA-4 + 49 | ||||
AA | 34(11) | 8(6) | 1 | |
GA | 118(39) | 60(48) | 2.16(0.94-4.96) | 0.07 |
GG | 148(49) | 57(46) | 1.64(0.72-3.75) | 0.24 |
A | 186(31) | 76(30) | 1 | |
G | 414(69) | 174(70) | 0.97(0.71-1.34) | 0.86 |
CTLA-4 CT60 | ||||
AA | 10(3) | 3(2) | 1 | |
GA | 82(27) | 32(26) | 1.30(0.34-5.04) | 0.70 |
GG | 208(69) | 90(72) | 1.44(0.39-5.36) | 0.58 |
A | 102(17) | 38(15) | 1 | |
G | 498(83) | 212(85) | 1.14(0.76-1.71) | 0.52 |