Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers

BMC Cancer

Table 2 miRNAs discriminating BRCA1 from sporadic basal cancers (fold change > 2.5, adjusted p < 0.05)

miRNA	Adjusted p value	Fold change	Expression in BRCA1 vs. basal	Cytoband	Correlation with previous BRCA1 CGH findings
hsa-miR-892a	0.0002	−7.98	Up	Xq27.3
hsa-miR-1247	0.0015	−6.26	Up	14q32.31
hsa-miR-129-3p	0.0001	−6.03	Up	11p11.2
hsa-miR-494	0.0014	−5.84	Up	14q31
hsa-miR-1273	0.0008	−5.43	Up	8q22.2	[53]
hsa-miR-198	0.0004	−5.34	Up	3q13.33	[54]
hsa-miR-30c-1*	<0.0001	−4.51	Up	1p34.2
hsa-miR-1281	0.0001	−3.88	Up	22q13.2
hsa-miR-220b	<0.0001	−3.76	Up	19p13.3
hsa-miR-566	<0.0001	−3.75	Up	3p21.31
hsa-miR-603	0.0003	−3.73	Up	10p12.1	[53, 55]
hsa-miR-675	0.0018	−3.53	Up	11p15.5
hsa-miR-637	0.0012	−3.31	Up	19p13.3
hsa-miR-576-3p	0.0014	−3.26	Up	4q25
hsa-miR-638	0.0366	−3.04	Up	19p13.2
hsa-miR-1826	<0.0001	−3.03	Up	16p11.2	[54]
hsa-miR-1268	0.0218	−2.96	Up	15q11.2	[53]
hsa-miR-1234	0.0076	−2.79	Up	8q24.3	[53, 56]
hsa-miR-1285	0.0428	−2.69	Up	7q21.2
hsa-miR-509-5p	0.0043	−2.53	Up	Xq27.3
hsa-miR-374b	0.0026	7.00	Down	Xq13.2	[53]
hsa-miR-590-3p	0.0101	5.25	Down	7q11.23
hsa-miR-218	0.0264	4.02	Down	4p15.31	[56]
hsa-miR-335*	0.0428	3.82	Down	7q32.2
hsa-miR-190b	0.0204	3.81	Down	1q21.3
hsa-miR-96	0.0405	3.48	Down	7q32.2
hsa-miR-454*	0.0405	3.21	Down	17q22
hsa-miR-576-5p	0.0218	3.03	Down	4q25
hsa-miR-340*	0.0111	3.01	Down	5q35.3	[53]
hsa-miR-29a*	0.0008	3.00	Down	7q32.3
hsa-miR-148b	0.0014	2.90	Down	17q13.13	[56]
hsa-miR-130b*	0.0076	2.89	Down	22q11.21
hsa-miR-149	0.0443	2.77	Down	17q37.3
hsa-miR-10a	0.0076	2.71	Down	17q21.32
hsa-miR-660	0.0428	2.56	Down	Xp11.23

ISSN: 1471-2407