(A) Metastases | Univariate | Multivariate | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
p-value | q-value | OR | 95%CI OR | AIC | n | p-value | q-value | OR | 95%CI OR | AIC | n | VIF | ROC AUC | R2 | ROC AUC | R2 | |||
Lower | Upper | Lower | Upper | Bootstrap | Cross-validation | ||||||||||||||
Average tumor size [mm] | 0.0001 | 0.004 | 1.070 | 1.038 | 1.113 | 53.46 | 76 | 0.0002 | 0.006 | 1.087 | 1.051 | 1.162 | 38.09 | 70 | 1.195 | 0.919 | 0.565 | 0.932 | 0.800 |
TMEM72 expression | 0.009 | 0.089 | 0.776 | 0.634 | 0.931 | 60.67 | 70 | 0.0113 | 0.105 | 0.738 | 0.555 | 0.884 | 1.195 | ||||||
Symptoms | 0.002 | 0.032 | 7.500 | 2.199 | 28.511 | 66.19 | 76 | Variables not in the multivariate model | |||||||||||
TMEM116 expression | 0.009 | 0.094 | 0.601 | 0.394 | 0.863 | 68.84 | 76 | ||||||||||||
TMEM61 expression | 0.019 | 0.139 | 0.790 | 0.634 | 0.945 | 60.44 | 68 | ||||||||||||
EPAS1 expression | 0.102 | 0.366 | 0.684 | 0.428 | 1.079 | 73.93 | 76 | ||||||||||||
(B) Fuhrman grade | Univariate | Multivariate | |||||||||||||||||
p-value | q-value | OR | 95%CI OR | AIC | n | p-value | q-value | OR | 95%CI OR | AIC | n | VIF | ROC AUC | R2 | ROC AUC | R2 | |||
Lower | Upper | Lower | Upper | Bootstrap | Cross-validation | ||||||||||||||
EPAS1 expression | 0.00004 | 0.002 | 0.235 | 0.107 | 0.433 | 78.70 | 76 | 0.0003 | 0.008 | 0.265 | 0.117 | 0.476 | 62.80 | 75 | 1.143 | 0.898 | 0.600 | 0.919 | 0.798 |
Smoking | 0.00177 | 0.018 | 4.764 | 1.837 | 13.153 | 98.75 | 76 | 0.0772 | 0.317 | 3.092 | 0.954 | 12.616 | 1.069 | ||||||
Average tumor size [mm] | 0.00299 | 0.032 | 1.039 | 1.015 | 1.067 | 98.11 | 76 | 0.004 | 0.054 | 1.048 | 1.023 | 1.099 | 1.241 | ||||||
TMEM30B expression | 0.00574 | 0.044 | 0.645 | 0.460 | 0.858 | 97.98 | 75 | 0.02 | 0.146 | 0.634 | 0.351 | 0.825 | 1.286 | ||||||
VHL expression | 0.0208 | 0.066 | 0.529 | 0.295 | 0.882 | 103.21 | 76 | Variables not in the multivariate model | |||||||||||
TMEM72 expression | 0.0255 | 0.150 | 0.832 | 0.699 | 0.970 | 95.22 | 70 | ||||||||||||
TMEM45B expression | 0.028 | 0.167 | 0.794 | 0.637 | 0.966 | 103.92 | 76 | ||||||||||||
TMEM116 expression | 0.0408 | 0.180 | 0.725 | 0.520 | 0.970 | 104.58 | 76 | ||||||||||||
SLC35G2 expression | 0.0442 | 0.222 | 0.811 | 0.651 | 0.985 | 103.38 | 75 |