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Table 4 Total frequency and mean ± SE of the micronucleus assay in peripheral blood cells

From: A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage

Experimental groups

Mean ± SE

%DI

24 h (T1)

48 h (T2)

72 h (T3)

 

Group 1

8.80 ± 0.58ª

10.40 ± 2.31ª

13.20 ± 1.74ª

-

Group 2

48.40 ± 1.21b

38.80 ± 2.96b

35.74 ± 1.79b

-

Group 3

12.40 ± 2.29ª

7.40 ± 0.81ª

12.40 ± 1.50ª

-

Group 4

9.20 ± 1.11ª

7.00 ± 0.89ª

14.00 ± 0.95ª

-

Group 5

63.80 ± 6.89c

NA

NA

38.81

Group 6

62.40 ± 1.36c

NA

NA

35.35

Group 7

NA

NA

NA

NA

  1. SE: Standard error
  2. NA: Not analysed
  3. %DI: Percentage of damage increase
  4. Different letters indicate statistically significant differences (p < 0.05; ANOVA/Tukey)