Skip to main content

Table 6 Host and bacterium variables associated with gastric cancer (n = 213) in comparison with gastritis (n = 174) in patients infected by H. pylori cagA-positive strains

From: STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer

Covariates

Univariate analysis

Multivariate analysis

p

OR

95 % CI

p

First modela

  Age

< 0.001

1.04

1.02 - 1.05

< 0.001

  Gender

< 0.001

3.58

2.10 - 6.09

< 0.001

  rs744166

0.007

1.64

1.16 - 2.31

0.005

  EPIYA-C number

< 0.001

2.28

1.41 - 3.68

0.001

Second modelb

  Age

< 0.001

1.05

1.05 - 1.06

< 0.001

  Gender

< 0.001

3.23

2.02 - 5.17

< 0.001

  rs744166 plus EPIYA-C number

< 0.001

3.01

2.29 - 3.97

< 0.001

  1. The Hosmer-Lemeshow tests showed good fit for models a(10 steps, 8 degrees of freedom; p = 0.42) b(10 steps, 8 degrees of freedom; p = 0.25), OR, odds ratio; 95 % CI: confidence interval. We constructed two models studying the loci, according to the amount of G rs744166 allele, treated as categorical variables having 3 values with 0 meaning the AA genotype, 1 the carrier of one G allele and 2 the GG genotype. In the second model the variable was obtained by the sum of the amount of STAT3 G allele and the number of EPIYA-C segments
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us