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Fig. 2 | BMC Cancer

Fig. 2

From: KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

Fig. 2

Dose-dependent effects of different KPT compounds in BPH-1, LnCaP (AR+/AD/p53wt), LAPC-4 (AR+/AD/p53mutant), 22rv1(AR+/AI/p53 wt) and PC3 (AR-/p53 null) cells treated with varying doses (0, 1, 10, 50, 100, 500 and 1000 nM) of different KPT compounds and assessed viability at 72 hours after treatment: KPT-127 (a), KPT-185 (b), KPT-207 (c), KPT-225 (d), KPT-251 (e) and KPT-330 (f). g IC50 for each compound was then calculated for the wide set of PCa cell lines

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BMC Cancer

ISSN: 1471-2407

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