Fig. 8

Epigenomic and genomic mutations associated with TF expression changes distinguishing PA I from AS II, AS III and GBM IV. TFs are displayed by circles. The circle size increases with the number of outgoing regulatory edges to other signature genes highlighting major regulators by large circles. Names of TFs strongly deviating from the center are shown in black. TFs belonging to selected annotation categories are highlighted by colored circles. Gene-specific changes in expression, DNA methylation or copy number are quantified by log-ratios comparing tumor to normal brain tissue. A log-ratio close to zero indicates no change in tumor, whereas a strong deviation from zero indicates a change. a, Average DNA methylation changes associated with TFs plotted against their average expression profiles in PA I. b, Average copy changes of TFs plotted against their average expression profiles in AS II, AS III and GBM IV