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Fig. 1 | BMC Cancer

Fig. 1

From: All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damage

Fig. 1

Combinational cytotoxicity of Topotecan (TPT) and ATRA. a Chemical structures of TPT and ATRA. b Combination of TPT and ATRA induce cytotoxicity in HL60, NB4 and U937 cells. 4 × 103 cells per well were cultured in 96-well plates and incubated with the indicated concentrations of TPT and ATRA for 48 h. Mean ± SD from three independent experiments. *: Compared to TPT group, p < 0.05. c CDI values at different ratio concentrations of TPT and ATRA (1 or 2 μM) were calculated by the proliferation inhibition rates. Each study was performed three times and the error bars represent the SD around the mean. d Cell morphology change was observed by microscope (magnification 200×) after combination of TPT and ATRA

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BMC Cancer

ISSN: 1471-2407

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