Fig. 3From: All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damageMitochondrial damage was involved in caspase-dependent apoptosis. a and b Effects of TPT, ATRA, or combination for 24 h on loss of mitochondrial membrane potential in HL60 cells were detected by flow cytometry after JC-1 staining. b The rates of red to green after HL60 Cells treated with TPT, ATRA, or combination for 24 h. c Effects of TPT, ATRA, or combination on Bcl-2, Bax and Cytochrome C protein expression were analyzed by western blotBack to article page