Table 3 Univariate and multivariate analyses of prognostic factors for disease-specific survival of CRC patients in the study cohort

Age (years)

≥60/<60

1.674

1.098-2.551

0.017

1.875

1.225-2.871

0.004

Sex

Male/female

1.141

0.791-1.646

0.480

Tumor location

Colon/rectum

0.960

0.674-1.367

0.820

Tumor size (cm)

≥5/<5

1.161

0.807-1.672

0.421

No. of examined lymph nodes

≥12/< 12

0.952

0.669-1.354

0.783

Bowel obstruction/perforation

Yes/no

0.962

0.355-2.607

0.940

Adjuvant chemotherapy

Yes/no

1.246

0.851-1.825

0.259

Differentiation grade

Poor well + moderate

1.691

1.103-2.591

0.016

TNM stage

III/I+ II

1.832

1.286-2.609

0.001

1.878

1.313-2.685

0.001

NETO2 expression

High/low

1.986

1.343-2.937

0.001

1.924

1.300-2.848

0.001