Fig. 3

Centrosome amplification correlates with high ploidy and high CIN. a Centrosome number correlates with ploidy. b-e Breast tumors were divided into two groups based on the presence or absence of CA, which was defined as having an average of >2 centrosomes per cell, as in Figure 2. Tumors with CA had higher average ploidy, as assessed by 6-chromosome FISH (b), polyploidy (c), and CIN, as assessed by the average non-modal chromosome number from FISH (e). d Centrosome number correlated with CIN. f Ploidy and CIN also correlated.