Fig. 3

Kenyan breast cancer tissue samples have increased macrophage infiltration in primary breast tumors. a Data plot analysis of IHC analysis for the macrophage lineage utilizing a CD68 antibody. Quantitative analysis of the staining indicates a significant increase in percent of CD68+ stained area (P < 0.0001; Mann-Whitney). b Data plot of IHC analysis for the M2 macrophage lineage utilizing a CD163 antibody. Quantitative analysis of the IHC staining revealed a significant increase in percent of CD163 stained area (P ≤ 0.0001; Mann-Whitney) in M2 macrophages in cancerous Kenyan breast tissues versus noncancerous Kenyan breast tissues. c Immunohistochemistry of representative noncancer and cancer samples for both general macrophage lineage (CD68) and the M2 macrophage lineage (CD163). Because the graphs are a log scale, any samples with unstained sections (i.e., zero) are not included in the graph. The bar represents the median of all samples in the indicated cohort and includes any unstained samples