Table 3 Characteristics and outcomes of survivors and non-survivors medical patients with advanced solid cancer in the ICU
Variables | Survivor (n = 120) | Non-survivor (n = 21) | P value |
|---|---|---|---|
Age | 62 (54–73) | 64 (55–74) | 0.448 |
Sex (male) | 72 (60 %) | 15 (71.4 %) | 0.692 |
Chronic health status | |||
Diabetes mellitus | 48 (40 %) | 9 (42.9 %) | 1.000 |
Chronic heart failure | 45 (37.5 %) | 3 (14.3 %) | 0.396 |
Hypertension | 27 (22.5 %) | 18 (85.7 %) | 0.003 |
Chronic renal failure | 0 (0) | 0 (0) | - |
Chronic bronchitis | 6 (5 %) | 0 (0) | 1.000 |
Types of solid cancer | |||
Stomach cancer | 33 (27.5 %) | 0 (0) | 0.004 |
Pancreas cancer | 19 (15.8 %) | 0 (0) | 0.075 |
Lung cancer | 9 (7.5 %) | 6 (28.6 %) | 0.011 |
Rectal cancer | 10 (8.3 %) | 0 (0) | 0.359 |
Colon cancer | 8 (6.7 %) | 2 (9.5 %) | 0.644 |
Esophageal cancer | 4 (3.3 %) | 2 (9.5 %) | 0.219 |
Breast cancer | 6 (5 %) | 0 (0) | 0.592 |
others | 32 (26.7 %) | 10 (47.6 %) | 0.066 |
History of antitumor therapy | |||
Surgery | 108 (90 %) | 15 (71.4 %) | 0.214 |
Chemotherapy | 60 (50 %) | 12 (57.1 %) | 1.000 |
radiotherapy | 15 (12.5 %) | 3 (14.3 %) | 1.000 |
biological therapy | 6 (5 %) | 0 (0) | 1.000 |
KPS | |||
Admit to hospital | 80 (50–90) | 40 (20–90) | 0.198 |
Admit to ICU | 10 (10–10) | 10 (10–10) | 0.310 |
Intervention time (hours) | 3 (1.3–7) | 24 (3–52) | 0.028 |
Major reasons for ICU | |||
Respiratory failure | 42 (35 %) | 12 (57.1 %) | 0.403 |
Severe sepsis or septic shock | 39 (32.5 %) | 0 (0) | 0.166 |
Acute renal failure | 6 (5 %) | 6 (28.6 %) | 0.100 |
Acute heart failure | 18 (15 %) | 0 (0) | 0.571 |
ICU therapeutic interventions | |||
vasopressors | 45 (37.5 %) | 15 (71.4 %) | 0.119 |
mechanical ventilation | 60 (50 %) | 21 (100 %) | 0.015 |
renal replacement therapy | 9 (7.5 %) | 6 (28.6 %) | 0.154 |
APCHE II score | |||
Day 1 | 20 (17–25) | 28 (26–35) | 0.001 |
Day 3 | 13 (10.25–16.75) | 29 (22–40) | 0.000 |
Day 7 | 11.5 (10–13.75) | 35 (23–41) | 0.000 |
SOFA score | |||
Day 1 | 7.5 (5–11.75) | 14 (12–19) | 0.002 |
Day 3 | 4.5 (2–7) | 17 (10–18) | 0.000 |
Day 7 | 3 (1–5) | 17 (11–23) | 0.000 |
Outcome | |||
Length of ICU stay (days) | 7 (5–10) | 3 (3–8) | 0.220 |
Overall survival (month) | 18.5 (4.25–31.5) | 6 (3–24) | 0.324 |