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Fig. 5 | BMC Cancer

Fig. 5

From: 3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

Fig. 5

Drug-induced loss of Ki67 is suppressed in 3D culture, BT474 and MDAMB361 cells were grown for 10 days as 2D monolayers or as 3D cultures in Matrigel in the presence of either trastuzumab and endocrine (tamoxifen or fulvestrant) monotherapy or their combination treatments. CON = control, HER = trastuzumab (Herceptin), TAM = tamoxifen, FAS = fulvestrant. ICC staining of BT474 (a) and MDAMB361 (b) cells for proliferative antigen Ki67 revealed less suppression of this antigen in 3D vs. 2D culture in response to treatments

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BMC Cancer

ISSN: 1471-2407

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