Skip to main content

Table 1 IC50 data for tamoxifen, fulvestrant and trastuzumab in 2D versus 3D culture conditions

From: 3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

Mean GI 50 (nM)

Cell line

Trastuzumab

Tamoxifen

Fulvestrant

 

3D

2D

3D

2D

3D

2D

BT474

13

1.7

>100

14.5

100

9

MDAMB361

>100

>100

88

9

76

8.3

  1. Cell growth data from Fig. 3 were analysed using GraphPad to obtain IC50 values. These were higher for both cell lines for each agent when cultured in 3D
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us