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Fig. 8 | BMC Cancer

Fig. 8

From: Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation

Fig. 8

A model deciphers molecular mechanisms by which PRMT5/p44 controls cell growth. PRMT5/p44 promotes cell cycle progression from G1 to S phase by increasing Rb phosphorylation and inhibiting p21 expression. PRMT5/p44 alters expression of oncogenes and tumor suppressors, which initiates cell growth. PRMT5/p44 also regulates cell growth and differentiation through the TGFβ signaling pathway

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BMC Cancer

ISSN: 1471-2407

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