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Table 2 Differences in FOLR1 mRNA expression and LINE1 DNA hypomethylation according to classical clinico-pathological characteristics

From: Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers

  

FOLR1 mRNA expressiona

LINE1-DNA hypomethylationb

  

Median value

p-value1

Median value

p-value1

Age (median value)

Lower

9.96

 

102.81

 

Higher

8.88

0.714

171.82

0.826

G1 VS G2-3

G1

2.55

 

88.40

 

G2-3

10.63

0.010**

138.34

0.436

FIGO stage

FIGO I, II

5.28

 

94.30

 

FIGO III, IV

11.94

<0.0001**

151.05

0.305

Residual disease

RD = 0

6.45

 

96.14

0.407

RD > 0

12.64

<0.0001**

152.06

 

Histology

Serous

14.04

 

118.29

 

Endometrioid

10.24

 

138.34

 

Clear cells

7.60

   

Mucinous

2.99

<0.0001**

104.06

0.533

Serous

14.04

 

118.29

 

Non-serous

6.00

<0.0001**

125.62

0.602

Mucinous

2.99

 

104.06

 

Non-mucinous

11.83

 

125.62

0.337

Platinum response

Refractory/resistant

6.82

0.049*

177.82

0.313

Sensitive

11.68

 

117.71

 

Type I/II

Type I

5.83

 

114.84

 

Type II

14.59

<0.0001**

134.67

0.345

  1. 1Mann Whitney Test. *Significant at the 0.05 level, **Significant at the 0.01 level, aArbitrary units normalized to TBP, bPUMR values
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BMC Cancer

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