Fig. 4From: Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinomaPredicted impact of SNS on protein function. Based upon computational prediction with PolyPhen-2, the observed shift toward increased numbers of C-to-A transversions is accompanied by an increased likelihood of accruing damaging variants in both the Unique-to-PTC and Unique-to-ANT Subsets (p < 0.0001)Back to article page