Table 9 Relative hazard for Nomo stages in derivation and external validation cohorts

≤82.0

ref

ref

ref

≤106.2

1.86

1.48–2.35

<0.0001

2.40

1.19–4.84

0.0147

1.92

1.37–2.70

0.0002

≤122.9

2.86

2.30–3.55

<0.0001

3.33

1.70–6.51

0.0004

3.38

2.48–4.62

<0.0001

≤138.2

3.91

3.17–4.82

<0.0001

4.83

2.54–9.22

<0.0001

5.13

3.81–6.91

<0.0001

≤153.0

5.58

4.55–6.84

<0.0001

6.60

3.50–12.42

<0.0001

7.87

5.89–10.51

<0.0001

≤170.7

8.47

6.95–10.33

<0.0001

10.41

5.60–19.32

<0.0001

12.17

9.19–16.13

<0.0001

≤192.2

12.46

10.25–15.14

<0.0001

16.23

8.84–29.81

<0.0001

18.39

13.91–24.3

<0.0001

≤225.6

22.40

18.49–27.13

<0.0001

21.11

11.53–38.67

<0.0001

32.19

24.47–42.34

<0.0001

≤272.1

40.47

33.46–48.94

<0.0001

42.87

23.56–78.00

<0.0001

65.32

49.79–85.68

<0.0001

272.1+

83.31

68.9–100.73

<0.0001

86.07

47.39–156.31

<0.0001

127.46

97.2–167.12

<0.0001

≤57.2

ref

ref

ref

≤70.0

2.16

1.83–2.56

<0.0001

1.96

1.19–3.22

0.0078

2.13

1.68–2.70

<0.0001

≤80.8

3.04

2.59–3.58

<0.0001

2.63

1.64–4.21

0.0001

3.12

2.49–3.92

<0.0001

≤90.7

4.76

4.08–5.56

<0.0001

4.28

2.73–6.71

<0.0001

5.55

4.48–6.87

<0.0001

≤101.6

6.12

5.26–7.12

<0.0001

6.17

3.99–9.55

<0.0001

6.90

5.59–8.52

<0.0001

≤114.2

9.01

7.76–10.45

<0.0001

8.41

5.47–12.92

<0.0001

11.11

9.06–13.63

<0.0001

≤129.1

13.46

11.62–15.58

<0.0001

11.25

7.36–17.19

<0.0001

15.23

12.45–18.62

<0.0001

≤147.1

18.68

16.15–21.61

<0.0001

16.81

11.04–25.61

<0.0001

24.23

19.85–29.57

<0.0001

≤171.8

28.44

24.61–32.88

<0.0001

25.47

16.76–38.68

<0.0001

37.66

30.91–45.89

<0.0001

171.8+

55.25

47.8–63.86

<0.0001

45.27

29.80–68.76

<0.0001

75.07

61.63–91.45

<0.0001