Table 5 Cox regression model to determine the effect of each symptom-to-diagnosis interval quartile on survival, adjusting for a) age, gender and b) age, gender and stage at diagnosis

Age

<0.001

1.02

1.01–1.03

<0.001

1.01

1.01–1.03

0.007

1.02

1.01–1.04

Gender (female)

0.029

0.81

0.67–0.98

0.009

0.73

0.58–0.92

0.872

1.03

0.73–1.45

SDI quartile

0.079

0.282

0.003

 1^st quartile

1

1

1

 2^nd quartile

0.979

1.00

0.75–1.34

0.798

1.04

0.76–1.43

0.022

0.59

0.38–0.93

 3^rd quartile

0.089

0.77

0.57–1.04

0.600

0.92

0.67–1.26

0.004

0.50

0.31–0.80

 4^rd quartile

0.104

0.78

0.59–1.05

0.115

0.76

0.54–1.07

0.001

0.46

0.29–0.74

Age

<0.001

1.02

1.01–1.03

0.001

1.02

1.01–1.03

0.003

1.03

1.01–1.05

Gender (female)

0.143

0.86

0.70–1.05

0.109

0.85

0.63–1.05

0.835

0.96

0.66–1.40

SDI quartile

0.115

0.160

0.084

 1^st quartile

1

1

1

 2^nd quartile

0.855

0.97

0.71–1.32

0.854

0.97

0.69–1.36

0.534

0.85

0.52–1.40

 3^rd quartile

0.088

0.76

0.55–1.04

0.176

0.79

0.56–1.11

0.003

0.56

0.34–0.94

 4^rd quartile

0.100

0.77

0.56–1.05

0.052

0.70

0.49–1.01

0.006

0.58

0.33–1.02

TNM stage at diagnosis

<0.001

<0.001

<0.001

 I

1

1

1

 II

0.002

2.07

1.29–3.33

0.083

1.72

0.93–3.18

0.003

3.23

1.51–6.92

 III

<0.001

3.17

1.99–5.05

0.002

2.57

1.40–4.72

<0.001

4.94

2.38–10.24

 IV

<0.001

12.40

7.56–19.81

<0.001

10.10

5.47–18.61

<0.001

19.07

9.05–40.15