Table 2 Summary of the IC50 values (μM) and resistance factors (RF) for CS, CB and OX as applied to the ovarian cancer A2780, A2780cisR, A2780ZD0473R and SKOV-3 cell lines. IC50 is the drug concentration required for 50 % cell kill and RF is the ratio of the IC50 value in the resistant A2780cisR and A2780ZD0473R cell lines over that in the responsive parent A2780 cell line
From: Changes in the in vitro activity of platinum drugs when administered in two aliquots
| Â | A2780 | A2780cisR | RF | A2780ZD0473R | RF | SKOV-3 |
|---|---|---|---|---|---|---|
CS | 0.5 ± 0.03 | 8.2 ± 0.6 | 17.7 | 6.0 ± 0.5 | 13.0 | 10.2 ± 0.5 |
CB | 14.0 ± 1.4 | 48.9 ± 3.9 | 3.5 | 64.6 ± 3.2 | 4.6 | 43.4 ± 3.9 |
OX | 0.2 ± 0.01 | 0.4 ± 0.02 | 1.9 | 0.4 ± 0.03 | 2.1 | 43.6 ± 3.0 |