Table 1 The demographic characteristics of the study cohort (n = 255)
From: Salivary DNA methylation panel to diagnose HPV-positive and HPV-negative head and neck cancers
Explanatory variables | Controls | Patients | |
|---|---|---|---|
HPV -ve | HPV + ve | ||
n = 122 (47.8 %) | n = 88 (34.5 %) | n = 45 (17.7 %) | |
Demographics | |||
 Gender | |||
  Male | 54 (44.3) | 67 (76.1) | 42 (93.3) |
  Female | 68 (55.7) | 21 (23.9) | 3 (6.7) |
 Age | |||
   < 50 | 66 (54.1) | 8 (8.6) | 7 (15.6) |
  50–59 | 42 (34.4) | 25 (26.9) | 17 (37.8) |
   > 60 | 14 (11.5) | 60 (64.5) | 21 (46.7) |
 Race and ethnicity | |||
  Caucasian | 107 (87.7) | 86 (97.7) | 43 (95.6) |
  Asian | 8 (6.6) | 0 (0) | 0 (0) |
  Other | 7 (5.7) | 2 (2.3) | 2 (4.4) |
Smoking | |||
 Pack/day smoked (cigarettes, cigar or pipe) | |||
  Non-smoker | 86 (70.5) | 14 (15.1) | 12 (26.7) |
  Ex-smoker | 7 (5.8) | 40 (43.0) | 23 (51.1) |
  1 to 19 | 17 (13.9) | 27 (29.0) | 8 (17.8) |
   > 20 | 6 (4.9) | 6 (6.5) | 2 (4.4) |
  Unknown | 6 (4.9) | 1 (1.1) | 0 (0) |
Drinking | |||
 No. Of years drank >15 drinks per week | |||
  Non-drinker | 9 (7.4) | 2 (2.3) | 5 (11.1) |
  Ex-drinker | 0 (0) | 3 (3.4) | 4 (8.9) |
  1 to 14 | 31 (25.4) | 6 (6.8) | 15 (33.3) |
   > 15 | 3 (2.4) | 11 (12.5) | 7 (15.6) |
  Unknown | 79 (64.8) | 66 (75.0) | 14 (31.1) |
Tumour characteristics | |||
 AJCC TNM stage | |||
  Stage 0 |  | 0 (0) | 0 (0) |
  Stage I |  | 17 (19.3) | 2 (4.4) |
  Stage II |  | 15 (17.0) | 2 (4.4) |
  Stage III |  | 10 (11.4) | 7 (15.6) |
  Stage IVa |  | 23 (26.1) | 26 (57.8) |
   Stage IVb |  | 2 (2.3) | 4 (8.9) |
   Stage IVc |  | 1 (1.1) | 0 (0) |
  Unknown |  | 20 (22.7) | 4 (8.9) |
 Tumour anatomic site | |||
  Oral cavity |  | 67 (76.1) | 4 (8.9) |
  Oropharynx |  | 11 (12.5) | 39 (86.7) |
  Hypopharynx |  | 2 (2.3) | 0 (0) |
  Larynx |  | 6 (6.8) | 1 (2.2) |
  Neck |  | 2 (2.3) | 1 (2.2) |