Salivary DNA methylation panel to diagnose HPV-positive and HPV-negative head and neck cancers

BMC Cancer

Table 3 The clinical performance for the individual tumour suppressor genes

HPV-status	Biomarker/Predictor	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC	p-value
HPV-negative	RASSF1a	41	92	66	80	0.69	<0.0001*
	p16 ^INK4a	47	69	62	55	0.55	0.12
	TIMP3	37	82	62	62	0.56	0.10
	PCQAP 5′	82	46	76	55	0.70	<0.0001*
	PCQAP 3′	34	85	62	64	0.59	<0.005*
HPV-positive	RASSF1a	68	40	75	32	0.53	0.77
	p16 ^INK4a	73	67	86	48	0.69	<0.005*
	TIMP3	27	92	75	58	0.51	0.94
	PCQAP 5′	81	44	84	38	0.62	<0.05*
	PCQAP 3′	76	63	86	46	0.68	<0.005*

The summary of predictive accuracy of the five individual DNA methylation genes in saliva collected from normal healthy controls and HPV-negative and HPV-positive HNSCC patients using Mann-Whitney’s U-test and receiver operative characteristic curve. Significant difference between each category was marked with *

ISSN: 1471-2407