No. (%) | ||||||
---|---|---|---|---|---|---|
Neg | Single | Double | Triple | Total | P Value | |
(1–10 fold) | >10 fold | |||||
(n = 37) | (n = 101) | (n = 172) | (n = 122) | (n = 432) | ||
Basic Characteristics | ||||||
Age | ||||||
< 45 | 2 (5.4) | 5 (5.0) | 12 (7.0) | 9 (7.4) | 28 | 0.057 |
45-60 | 22 (59.5) | 50 (49.5) | 61 (35.5) | 43 (35.2) | 176 | |
> 60 | 13 (35.1) | 46 (45.5) | 99 (57.6) | 70 (57.4) | 228 | |
Sex | ||||||
Male | 27 (73.0) | 71 (70.3) | 114 (66.3) | 84 (68.9) | 296 | 0.827 |
Female | 10 (27.0) | 30 (29.7) | 58 (33.7) | 38 (31.1) | 136 | |
Histological classification | ||||||
SCC | 12 (32.4) | 29 (28.7) | 49 (28.5) | 29 (23.8) | 119 | 0.772 |
ADC | 19 (51.4) | 53 (52.5) | 90 (52.3) | 63 (51.6) | 225 | |
SCLC | 3 (8.1) | 12 (11.9) | 24 (14) | 24 (19.7) | 63 | |
Others | 3 (8.1) | 7 (6.9) | 9 (5.2) | 6 (4.9) | 25 | |
Stages | ||||||
I | 5 (13.5) | 8 (7.9) | 5 (2.9) | 0 (0) | 18 | <0.05* |
II | 2 (5.4) | 6 (5.9) | 5 (2.9) | 4 (3.3) | 17 | |
III | 14 (37.8) | 34 (33.7) | 43 (25) | 37 (30.3) | 128 | |
IV | 14 (37.8) | 47 (46.5) | 109 (63.4) | 73 (59.8) | 243 | |
#Un. | 2 (5.4) | 6 (5.9) | 10 (5.8) | 8 (6.6) | 26 | |
Smoke status | ||||||
No | 16 (43.2) | 54 (53.5) | 73 (42.4) | 48 (39.3) | 191 | 0.178 |
Yes | 21 (56.8) | 47 (46.5) | 99 (57.6) | 74 (60.7) | 241 | |
Metastasis | ||||||
Brain | ||||||
No | 34 (91.9) | 91 (90.1) | 143 (83.1) | 103 (84.4) | 371 | 0.277 |
Yes | 3 (8.1) | 10 (9.9) | 29 (16.9) | 19 (15.6) | 61 | |
Bone | ||||||
No | 33 (89.2) | 87 (86.1) | 127 (73.8) | 88 (72.1) | 335 | <0.05* |
Yes | 4 (10.8) | 14 (13.9) | 45 (26.2) | 34 (27.9) | 97 | |
Liver | ||||||
No | 36 (97.3) | 94 (93.1) | 155 (90.1) | 106 (86.9) | 391 | 0.199 |
Yes | 1 (2.7) | 7 (6.9) | 17 (9.9) | 16 (13.1) | 41 | |
Adrenal gland | ||||||
No | 36 (97.3) | 98 (97) | 154 (89.5) | 117 (95.9) | 405 | 0.086 |
Yes | 1 (1.7) | 3 (3.0) | 18 (10.5) | 5 (4.1) | 27 | |
Lymph node | ||||||
No | 25 (67.6) | 45 (44.6) | 69 (40.1) | 32 (26.2) | 171 | <0.001** |
Yes | 12 (32.4) | 56 (55.4) | 103 (59.9) | 90 (73.8) | 261 | |
Intrapulmonary | ||||||
No | 33 (89.2) | 89 (88.1) | 149 (86.6) | 108 (88.5) | 379 | 0.950 |
Yes | 4 (10.8) | 12 (11.9) | 23 (13.4) | 14 (11.5) | 53 | |
Pleural | ||||||
No | 33 (89.2) | 89 (88.1) | 142 (82.6) | 104 (85.2) | 368 | 0.552 |
Yes | 4 (10.8) | 12 (11.9) | 30 (17.4) | 18 (14.8) | 64 | |
Mediastinal | ||||||
No | 37 (100) | 98 (97) | 169 (98.3) | 114 (93.4) | 418 | 0.080 |
Yes | 0 (0.0) | 3 (3.0) | 3 (1.7) | 8 (6.6) | 14 | |
Peritoneum | ||||||
No | 37 (100) | 98 (93.7) | 162 (94.2) | 112 (91.8) | 409 | 0.153 |
Yes | 0 (0.0) | 3 (6.3) | 10 (5.8) | 10 (8.2) | 23 | |
Validation group | ||||||
No. (%) | ||||||
Neg | Single | Double | Triple | Total | P Value | |
(n = 27) | (n = 118) | (n = 161) | (n = 130) | (n = 436) | ||
Basic Characteristics | ||||||
Age | ||||||
2 (7.4) | 8 (6.8) | 10 (6.2) | 11 (8.5) | 31 | 0.733 | |
10 (37.0) | 46 (39.0) | 48 (29.8) | 45 (34.6) | 149 | ||
15 (55.6) | 64 (54.2) | 103 (64.0) | 74 (56.9) | 256 | ||
Sex | ||||||
18 (66.7) | 75 (63.6) | 116 (72.0) | 98 (75.4) | 307 | 0.204 | |
9 (33.3) | 43 (36.4) | 45 (28.0) | 32 (24.6) | 129 | ||
Histological classification | ||||||
7 (25.9) | 31 (26.3) | 37 (23) | 21 (16.2) | 96 | 0.386 | |
15 (55.6) | 57 (48.3) | 84 (52.2) | 64 (49.2) | 220 | ||
1 (3.7) | 5 (4.2) | 11 (6.8) | 7 (5.4) | 24 | ||
5 (18.5) | 12 (10.2) | 7 (4.3) | 24 (18.5) | 47 | ||
Stages | ||||||
5 (18.5) | 9 (7.6) | 5 (3.1) | 3 (2.3) | 22 | <0.05* | |
5 (18.5) | 16 (13.6) | 10 (6.2) | 7 (5.4) | 38 | ||
6 (22.2) | 26 (22.0) | 36 (22.4) | 21 (16.2) | 89 | ||
11 (40.7) | 58 (49.2) | 103 (64.0) | 90 (69.2) | 262 | ||
0 (0.0) | 9 (7.6) | 7 (4.3) | 9 (19.2) | 25 | ||
Smoke status | ||||||
15 (55.6) | 62 (52.5) | 65 (40.4) | 49 (37.7) | 191 | <0.05* | |
12 (44.4) | 56 (47.5) | 96 (59.6) | 81 (62.3) | 245 | ||
Metastasis | ||||||
Brain | ||||||
27 (100.0) | 107 (90.7) | 134 (83.2) | 110 (84.6) | 378 | <0.05* | |
0 (0.0) | 11 (9.3) | 27 (16.8) | 20 (15.4) | 58 | ||
Bone | ||||||
27 (100.0) | 103 (87.3) | 123 (76.4) | 87 (66.9) | 340 | <0.001** | |
0 (0.0) | 15 (12.7) | 38 (23.6) | 43 (33.1) | 96 | ||
Liver | ||||||
No | 26 (96.3) | 111 (94.1) | 140 (87.0) | 106 (81.5) | 383 | <0.05* |
Yes | 1 (3.7) | 7 (5.9) | 21 (13.0) | 24 (18.5) | 53 | |
Adrenal gland | ||||||
27 (100.0) | 111 (94.1) | 149 (92.5) | 122 (93.8) | 409 | 0.525 | |
0 (0.0) | 7 (5.9) | 12 (7.5) | 8 (6.2) | 27 | ||
Lymph node | ||||||
19 (70.4) | 58 (49.2) | 50 (31.1) | 40 (30.8) | 167 | <0.001*** | |
8 (29.6) | 60 (50.8) | 111 (68.9) | 90 (69.2) | 269 | ||
Intrapulmonary | ||||||
26 (96.3) | 105 (89.0) | 130 (80.7) | 114 (87.7) | 375 | 0.064 | |
1 (3.7) | 13 (11.0) | 31 (19.3) | 16 (12.3) | 61 | ||
Pleural | ||||||
25 (92.6) | 107 (90.7) | 129 (80.1) | 104 (80.0) | 365 | <0.05* | |
2 (7.4) | 11 (9.3) | 32 (20.8) | 26 (20.0) | 71 | ||
Mediastinal | ||||||
27 (100.0) | 116 (98.3) | 152 (94.4) | 123 (94.6) | 418 | 0.229 | |
0 (0.0) | 2 (1.7) | 9 (5.6) | 7 (5.4) | 18 | ||
Peritoneum | ||||||
27 (100.0) | 110 (93.2) | 144 (89.4) | 118 (90.8) | 399 | 0.269 | |
0 (0.0) | 8 (6.8) | 17 (10.4) | 12 (9.2) | 37 |