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Table 4 Metabolic characteristics of child survivors of leukemia and lymphoma according to treatment at 6-months

From: Adipokines, insulin resistance, and adiposity as a predictors of metabolic syndrome in child survivors of lymphoma and acute lymphoblastic leukemia of a developing country

 

Treatment

Chemotherapya n = 32

Chemotherapy plus radiotherapy n =17

Variables

Normal

Overweigth/Obese

Normal

Overweigth/Obese

 n: number (%)

18

14 (40)

9

8 (47)

 Sex: M

13

11

6

7

 Current age (Y)

12.5 (8.0, 17.1)

11.6 (8.0, 17.1)

14.0 (8.4, 17.0)

13.0 (8.1, 18.0)

 Age at cancer diagnosis (Y)

6.0 (2, 13)

4.0 (2, 12)

6.0 (0.08, 12)

70 (1.0, 11.1)

 Time since completion of therapy (Y)

4.0 (2.1, 5.0)

4.0 (2.1, 5.0)

3.1 (3.0, 5.0)

4.0 (2.0, 5.0)

 Δ Body weight (kg) (6 mo - first assessement)

1.6 (−2.5, 5.3)

 

2.0 (−1.2, 5.1)

 

 Δ Height (cm) (6 mo - first assessment)

2.6 (1.7, 6.0)

 

1.0 (0.2, 3.5)*

 

Diagnosis : ALL/Lymphoma

11/7

9/5

3/6

2/6

Pubertal stage

 1

8

9

3

2

 ≥ 2

10

5

6

6

MS Components

 WC (pc)

25 (10, 50)

90 (35, 100)*

30 (10, 50)

83 (50, 90)**

 SBP (pc)

15.5 (0, 55)

64 (2, 95)*

13 (1, 38)

21 (3, 65)

 DBP (pc)

54 (22, 92)

87 (13, 99)*

53 (38, 79)

71 (39, 85)

 Triglicerydes (mg/dL)

80 (28, 191)

124 (66, 264)*

91 (28, 259)

105 (56, 218)

 HDL-C (mg/dL)

47.3 (24.6, 79.5)

38.5 (21.7, 67.6)*

46 (32, 56)

37 (20, 60)

 Glucose (mg/dL)

93 (76.6, 102)

97.5 (83.5, 115)

88.5 (76.6, 100.6)

92.6 (82.7, 101.2)

Others metabolic variables

 Insulin (μU/mL)

25 (8.3, 35.4)

33.4 (22.8, 64)*

14.9 (3.4, 43.9)

28.9 (16.9, 52.3)

 HOMA-IR

4.8 (1.7, 7.0)

7.8 (5.2, 15.4)*

3.4 (0.68, 10.9)

6.6 (4.0, 11.4)

 Adiponectin (μg/mL)

21.9 (7.7, 42.1)

20.2 (6.6, 57.3)

20.9 (11.6, 28.9)

15.3 (0.64, 33.0)

 Adiponectin per Kg fat (μg/mL/kg)

1.7 (0.45, 14.3)

1.0 (0.27, 4.2)

1.9 (0.62, 4.2)

0.78 (0.06, 6.6)

 Leptin ((μg/mL)

5.2 (1.8, 30.9)

21 (9.4, 40.7)*

6.2 (1.6, 25.1)

9.5 (3.6, 27.6)

 Leptin per Kg fat (μg/mL/kg)

0.63 (0.13, 2.6)

1.1 (0.30, 4.4)*

0.39 (0.11, 4.8)

0.67 (0.13, 4.2)

 Leptin to Adiponectin ratio

0.26 (0.05, 1.1)

1.2 (0.81, 3.5)*

0.34 (0.11, 1.2)

0.93 (0.11, 10.4)

 Body Fat (%)

22 (11.2, 35.7)

39.8 (33.4, 49.3)*

23 (10.9, 43.4)

30.7 (18.7, 37.7)

 VCAM (ng/mL)

801 (503, 2045)

818 (514, 1522)

617 (377, 1166)

727 (394, 1178)

 ICAM (ng/mL)

404 (234, 753)

440 (200. 1124)

571 (184, 966)

411 (307, 1037)

MS

 Yes/No

0/18

7/14

0/9

3/5

  1. Values are median (min, max); Abbreviations: MS Metabolic syndrome, HOMA-IR Homeostatic Model Assessment of Insulin Resistance, VCAM Vascular cell adhesion molecule, ICAM Intercellular adhesion molecule. Data compared Mann–Whitney U-test. Categorized Data were analyzed using Fisher’s Test. aThree children of Chemotherapy group were excluded, because they were underweight; * p value < 0.05; **p value = 0.065
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BMC Cancer

ISSN: 1471-2407

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