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Table 2 Chromosomal translocations identified by SKY analysis in grade II meningioma fragments 2, 3 and 4

From: First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation

 

Metaphase state

Normal

Abnormal

Shattered

Sample

 

Non-recurrent

Recurrent

 

Grade II-2

40%

40%

0%

20%

 

46, XX, t(10;18)

  
 

46, XX, t(1;8)

  
 

46, XX, t(5;14)

  

Grade II-3

20%

30%

50%

0%

 

46, XX, t(11;8)

46, XX, t(8;8), t(11;12)

 
 

46, XX, t(1;2), t(2;4), t(7;8), t(9;21)

  
 

46, XX, t(1;3;22), t(11;21), t(2;18)

  

Grade II-4

20%

0%

80%

0%

  

46, XX, t(3;13;14), t(17;21)

 
  

46, XX, t(3;13;14), t(17;21), inv(12)

 
  1. Percent of normal metaphases and metaphases containing chromosomal translocations (abnormal) is shown in the top row for each meningioma grade II primary tissue culture analyzed (Grade II-2, II-3 and II-4, note that culture from fragment II-1 could not be established). Abnormal metaphases were further divided into recurrent or non-recurrent. Fragment 2 of the tumor (Grade II-2) also contained 20% of cells with highly fragmented, shattered chromosomes
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BMC Cancer

ISSN: 1471-2407

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