Fig. 6
TanIIA inhibited the melanoma A375 cell induced tumor development in the mouse model. The mice were inoculated with the melanoma A375 cells to induce tumor as described in the Methods. At 14 days post transplantation when the tumor volume was about 50–100 mm3, the mice were randomly assigned to four groups with 6 mice in each group. The selected mice were inoculated with 100 μ of PBS (Untreated Control), Paclitaxel (8 μg/g), Tan II (A) (25 μg/g), or Tan II (A) (50 μg/g) respectively. The mice were sacrificed at day 28 post treatments. The tumors were harvested, weighted, and recorded. a. TanIIA and Paclitaxel treatments modestly reduced mouse weight. b. TanIIA and Paclitaxel treatments significantly inhibited tumor volume. c. TanIIA and Paclitaxel treatments significantly reduced tumor weight at day 28 post treatments. d. The display image of of harvested mice from Untreated Control, Paclitaxel (8 μg/g), Tan II (A) (25 μg/g), or Tan II (A) (50 μg/g) treatments respectively. e. The visualize images of mice tumor. TanIIA and Paclitaxel treatments significantly decreased tumor size at day 28 post treatments