Study | Cohort and treatment | NLR cut-off | Results | p16 status |
---|---|---|---|---|
Rachidi et al. [13] | n = 543 HNSCC (170 OC), any treatment (2000–2012) | 4.39 (upper tertile) | - Increased mortality for high NLR (HR = 2.39) - NLR prognostic factor both in p16-pos. And neg. Pts. - NLR significantly lower in p16-pos. Patients | yes (89/543) |
Charles et al. [29] | n = 145 (76 OC), radio(chemo)therapy (2005–2012) | 5.0 (based on review [39]) | - High NLR associated in OC with inferior OS (HR = 4.6) and RFS (HR = 3.01) - No subgroup analysis for p16 pos. Pts. | yes (95/145) |
Kano et al. [40] | n = 285 HNSCC (116 OC), radiochemotherapy (2003–2012) | 1.92 (based on ROC analysis) | - High NLR associated with inferior OS and DFS, but not significant on multivariate analysis | no |
Valero et al. [35] | n = 824 (203 OC), any treatment (2010–2012) | 1.35 and 3.86 (three groups based on RPA) | - High NLR associated with inferior DSS - Lower neutrophil number in p16 pos. Pts. | yes (125/824) |
Selzer et al. [14] | n = 170 (74 OC), primary radio(chemo)therapy or radioimmunotherapy (2002–2012) | 5.0 | - High NLR associated with inferior median OS (17 vs. 27 months) | no |
Moon et al. [41] | n = 153 (51 OC), HNSCC prospective study (2010–2012) | not described | - High NLR associated with inferior PFS (HR = 2.20) and OS (HR = 3.22) | no |
Huang et al. [34] | n = 510, OC, radio(chemo)therapy (2000–2010) | not applied (neutrophils and lymphocytes were analyzed separately) | - High neutrophils and low lymphocytes are associated with inferior prognosis - Reduced neutrophil count and similar lymphocyte count in p16-pos. Pts. | yes (all) |
Young et al. [42] | n = 249, OC, radio(chemo)therapy (2004–2010) | 5.0 | - High NLR associated with inferior locoregional control (HR = 2.072) | no |