Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia – identification of responders by gene expression profiling of pretreatment leukemic cells

Reikvam, Håkon; Hovland, Randi; Forthun, Rakel Brendsdal; Erdal, Sigrid; Gjertsen, Bjørn Tore; Fredly, Hanne; Bruserud, Øystein

doi:10.1186/s12885-017-3620-y

Table 1 Comparison of global gene expression profiles for responders and non-responders to AML stabilizing treatment based on ATRA and valproic acid – a summary of the results from the Gene Set Enrichment Analysis (GSEA)

From: Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia – identification of responders by gene expression profiling of pretreatment leukemic cells

GENE SET	SIZE	ES	NES	NOM P-VALUE
Signal sequence binding	21	−0.62	−1.85	<0.01
Olfactory bulb interneuron development	10	−0.72	−1.77	<0.01
Negative regulation of MAPK cascade	38	−0.5	−1.76	<0.01
Response to ionizing radiation	85	−0.45	−1.69	<0.01
Zinc ion transport	16	−0.67	−1.76	0.01
Pre-mRNA binding	13	−0.7	−1.73	0.01
Positive regulation of oxidoreductase activity	14	−0.65	−1.73	0.01
Inactivation of MAPK activity	27	−0.48	−1.62	0.01
Regulation of interferon-gamma biosynthetic process	16	−0.6	−1.61	0.01
Carboxylic acid catabolic process	34	−0.45	−1.61	0.01
Response to radiation	189	−0.37	−1.56	0.01
Negative regulation of reactive oxygen species metabolic process	11	−0.64	−1.68	0.02
Regulation of bone resorption	10	−0.7	−1.66	0.02
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	11	−0.62	−1.65	0.02
Biotin metabolic process	10	−0.73	−1.65	0.02
Regulation of isotype switching	20	−0.55	−1.64	0.02
Fucosyltransferase activity	14	−0.64	−1.65	0.03
Microtubule bundle formation	24	−0.52	−1.6	0.03
Negative regulation of JNK cascade	22	−0.59	−1.59	0.03
UV protection	11	−0.6	−1.56	0.03
MutSalpha complex binding	11	−0.72	−1.59	0.04
Aminopeptidase activity	34	−0.47	−1.58	0.04
Mismatch repair complex	10	−0.74	−1.57	0.04
Negative regulation of transcription by competitive promoter binding	10	−0.61	−1.56	0.04
Cholesterol efflux	25	−0.51	−1.55	0.04
Negative regulation of cytoskeleton organization	51	−0.41	−1.51	0.04
Regulation of protein localization to cell surface	17	−0.53	−1.51	0.04
Response to gamma radiation	32	−0.44	−1.47	0.04

Abbreviations: ES enrichment score JNK c-Jun N-terminal kinases, MAPK mitogen-activated protein kinase, NES normalized enrichment score

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ISSN: 1471-2407

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