Table 2 Cell lines and other materials, and characteristics of articles considered in this review

Overexpression of PGC-1α enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein

HT-29 (Cell line)

i) Human.

ii) Epithelial

SNU-C4 (Cell line)

i) Human

CT-26 (Cell line)

i) Mouse.

ii) Epithelial

PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine

iPGC1b mouse model with human PGC1b

i) Transgenic mouse

iPGC1b knockout mice

iPGC1b Apc Min/+ Mice

Mitochondria and Tumor Progression in Ulcerative Colitis

Ulcerative Colitis progressor (Human)

i) Human

Ulcerative Colitis non progressor (Human)

PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

PGC1a knockout mice

i) Transgenic mouse

PGC1a +/+ mice

SCID mice (HT29)

i) Inoculated mouse

HT29 (Cell line)

i) Human.

ii) Epithelial

Colo205 (Cell line)

i) Human.

ii) Epithelial

Bax is necessary for PGC1α pro-apoptotic effect in colorectal cancer cells

HCT116 (Cell line)

Nude mice (subcutaneously injected both cells)

i) Human

ii) Epithelial

i) Inoculated mouse

PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations

VACO425 (Cell line)

i) Human

VACO429 (Cell line)

i) Human

Validation of the Use of DNA Pools and Primer Extension in Association Studies of Sporadic Colorectal Cancer for Selection of Candidate SNPs

Two pools of genomic DNA (patients with sporadic CRC + controls)

i) Human

SIRT1/PGC1a-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

Colonosphere cultures shSIRT1 (Human colorectal tumor specimens)

i) Human colonosphere cultures

Colonosphere cultures shPGC1a (Human colorectal tumor specimens)

AMPK Promotes Aberrant PGC1b Expression To Support Human Colon Tumor Cell Survival

HCT116 (Cell line)

i) Human.

ii) Epithelial

Inmunodeficient mice (HCT116 cells grafted into mice)

i) Inoculated mouse

Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a metabolic regulator of intestinal epithelial cell fate

HT29 (Cell line)

i) Human.

ii) Epithelial

HCT116 (Cell line)

i) Human.

ii) Epithelial

HT29p0 (Cell line: Completely lacks mitochondrial DNA)

i) Human.

ii) Epithelial

Xenograft mice using HT29 cells

i) Inoculated mouse

iPGC1a transgenic mice

i) Transgenic mouse

PGC1a +/+ mice and PGC1−/− mice

Peroxisome Proliferator-Activated Receptor gamma Coactivator-1 Enhances Antiproliferative Activity of 5 -Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase

Colo320 (Cell line)

i) Human.

ii) Undifferentiated

HCT116 (Cell line)

i) Human.

ii) Epithelial

Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARg-coactivator 1 (PGC-1)

Colorectal cancers from patients (Human)

i) Human