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Table 3 Multivariate analysis of clinicopathologic factors associated with overall survival†

From: Effect of total number of harvested lymph nodes on survival outcomes after curative resection for gastric adenocarcinoma: findings from an eastern high-volume gastric cancer center

Risk factors

All Stages

Stage IIIA

HR

95% CI

p a

HR

95% CI

p a

Age, years

  < 65

1.00

Reference

 

1.00

Reference

 

  ≥ 65

1.99

1.70–2.33

< .001

2.23

1.51–3.30

< .001

BMI

0.95

0.92–0.97

< .001

   

ASA

 I

1.00

Reference

    

 II

1.25

1.06–1.48

0.008

   

 III

2.24

1.71–2.93

< .001

   

pT category

 T1

1.00

Reference

    

 T2

0.83

0.56–1.24

0.366

   

 T3

1.10

0.72–1.66

0.663

   

 T4

2.00

1.29–3.09

0.002

   

pN category

 N0

1.00

Reference

    

 N1

1.44

1.10–1.87

0.007

   

 N2

1.79

1.36–2.35

< .001

   

 N3

3.45

2.64–4.50

< .001

   

Total number of LN examined

 0–30

1.00

Reference

 

1.00

Reference

 

 30–45

1.05

0.86–1.28

0.614

0.87

0.53–1.45

0.580

  > 45

0.96

0.79–1.18

0.721

0.56

0.33–0.95

0.030

Tumor location

 Proximal

1.00

Reference

    

 Middle

1.27

1.00–1.61

0.051

   

 Distal

1.35

1.05–1.75

0.020

   

 Whole

1.66

1.15–2.40

0.007

   

Histologic grade*

 Differentiated

1.00

Reference

    

 Undifferentiated

0.85

0.72–1.00

0.045

   

 Others

2.69

1.74–4.15

< .001

   

Borrmann type

 0

1.00

Reference

    

 I

1.73

0.92–3.25

0.089

   

 II

1.43

0.95–2.15

0.085

   

 III

1.85

1.28–2.68

0.001

   

 IV

2.27

1.41–3.65

0.001

   

 V

1.29

0.31–5.42

0.732

   

Lymphovascular invasion

 Absent

1.00

Reference

    

 Present

1.31

1.08–1.60

0.007

   

Resection type

 Subtotal

1.00

Reference

    

 Total

1.20

0.98–1.49

0.084

   

 Extended

1.55

1.16–2.06

0.003

   
  1. Abbreviations: BMI body mass index, ASA American Society of Anesthesiology, pT pathologic tumor, pN pathologic nodal status
  2. †Only factors found to be statistically significant, except for total number of LN examined, reported. For all variables, refer to Additional file 4: Table S1
  3. ap values indicate a relative statistical significance for each category compared to the reference category in each variable (HR 1.00)
  4. *Differentiated histology included papillary adenocarcinoma, well-differentiated and moderately-differentiated tubular adenocarcinoma. Undifferentiated histology included poorly differentiated adenocarcinoma, signet ring cell adenocarcinoma, and mucinous carcinoma. Others included adenosquamous, squamous, neuroendocrine, etc.
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BMC Cancer

ISSN: 1471-2407

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